Understanding Sustamine® – L-Alanyl L-Glutamine

//, Research, Supplements/Understanding Sustamine® – L-Alanyl L-Glutamine

The Role of Hydration in Athletic Stamina

Maintaining hydration levels is a vital part of our well-being. When we push our bodies and minds to the limit, the need to stay hydrated increases. It has been shown that when exercising in a hot environment, dehydration by only 2% of body mass reduces our level of performance and makes us more susceptible to suffering from heat-related injuries. By negating our hydration, we are actively making a decision to perform at a lower level and to risk overall injury.

The reality of exercise and sport, however, is that it is not always easy to maintain our hydration levels. Yes, at times, we can sense that we are dehydrated and that we need to rehydrate, but the opportunity to do so does not always present itself. If we are playing a team sport, there needs to be a break in the game for us to get a drink, which is often only a short opportunity. If we are running a marathon there are water stations, sure, but to stay fully hydrated is water alone enough? The reality of sport is that hydration levels can be challenging to maintain, regardless of the athletic activity.

What is Sustamine®?

Sustamine® is a unique, revolutionary dipeptide form of L-Glutamine and is designed to be ingested in energy drinks, nutritional bars, yogurts and dietary supplements. It is taste-free, odor-free, allergen-free and Kosher. Sustamine® consists of L-Alanyl-L-Glutamine, which means it offers a combination of pure L-Glutamine to support muscle protein synthesis and L-Alanine to help rebuild glycogen stores. More than half of the body’s free amino acid pool consists of glutamine. It is able to limit intestinal permeability and reduce gut atrophy by being involved in many metabolic and synthetic biochemical processes.

In order for substances and nutrients to be absorbed by the body when they are ingested, it is necessary for them to pass through the intestinal barrier. If this barrier is performing optimally, it will act as a sieve to allow the substances to pass through. Glutamine has been shown to help the body maintain the physiologic intestinal barrier when there are stresses acting on the body. These stresses, whether as a result of mental or physical exertion in the form of exercise or illness, have the potential to lower this level. This makes us more susceptible to infections. Sustamine® provides the body with L-Glutamine to help maintain this barrier at peak condition. Sustamine® has also been shown to be better absorbed within the gut than a pure dose of glutamine alone, meaning the body is able to take on more glutamine when it is supplied as Sustamine®.

The Many Benefits of Sustamine®

Another significant benefit of Sustamine®’s ability to support the intestinal barrier is that the immune system is strengthened. Further links between Sustamine® and warding off exhaustion have also been made. By reducing your level of exhaustion, you enable your body to allot more energy, if needed, towards overall immunity.

Investigations on L-Alanyl-L-Glutamine’s ability to positively influence hydration and support the performance levels of athletes has been thoroughly examined. A paper in 2010 showed that time to exhaustion was increased through the provision of a significant ergogenic benefit from Sustamine® supplementation. This effect was deemed to be likely as a result of the enhanced fluid and electrolyte uptake that the L-Alanine-L-Glutamine provided. Another study conducted on basketball players showed rehydration levels from Sustamine® supplementation supported skill performance and visual reaction time better than water alone.

Further links on performance have also been made between Sustamine® and reducing muscle protein breakdown after resistance exercise and supporting athlete reaction times during endurance exercise.

Summary of Sustamine®’s Sport Performance/Health Benefits:

  • Supports Muscle Protein Synthesis†
  • Supports Glycogen Store Replenishment†
  • Supports Hydration Levels†
  • Supports Recovery from Exercise†
  • Supports Athletic Performance†
  • Supports Overall Immunity†
  • Optimal Absorption through Sport Oxylent®’s Effervescence Delivery†

Sport Oxylent® contains 250mg of Sustamine® per serving to support hydration levels, recovery, immunity and overall athletic performance for all types of athletes.

As a 3-in-1 effervescent performance drink, Sport Oxylent® combines a natural blend of vitamins, minerals, electrolytes and antioxidants that can be taken either before, during or after your workout.

As with all Vitalah® products, Sport Oxylent® contains no gluten, dairy, soy, caffeine, GMOs or sugar!



Déchelotte, P., Hasselmann, M., Cynober, L., Allaouchiche, B., Coëffier, M., Hecketsweiler, B., … & Petit, J. (2006). L-alanyl-L-glutamine dipeptide–supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: The French controlled, randomized, double-blind, multicenter study. Critical care medicine34(3), 598-604.

De-Souza, D. A., & Greene, L. J. (2005). Intestinal permeability and systemic infections in critically ill patients: effect of glutamine. Critical care medicine33(5), 1125-1135.

Harris, R. C., Hoffman, J. R., Allsopp, A., & Routledge, N. B. (2012). L-glutamine absorption is enhanced after ingestion of L-alanylglutamine compared with the free amino acid or wheat protein. Nutrition research32(4), 272-277.

Hoffman, J. R., Ratamess, N. A., Kang, J., Rashti, S. L., Kelly, N., Gonzalez, A. M., … & Hom, L. L. (2010). Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise. Journal of the International Society of Sports Nutrition7(1), 8.

McCormack, W. P., Hoffman, J. R., Pruna, G. J., Jajtner, A. R., Townsend, J. R., Stout, J. R., … & Fukuda, D. H. (2015). Effects of L-alanyl-L-glutamine ingestion on one-hour run performance. Journal of the American College of Nutrition34(6), 488-496.

Pruna, G. J., Hoffman, J. R., McCormack, W. P., Jajtner, A. R., Townsend, J. R., Bohner, J. D., … & Fukuda, D. H. (2016). Effect of acute L-Alanyl-L-Glutamine and electrolyte ingestion on cognitive function and reaction time following endurance exercise. European journal of sport science16(1), 72-79.

Wang, W., Choi, R. H., Solares, G. J., Tseng, H. M., Ding, Z., Kim, K., & Ivy, J. L. (2015). L-Alanylglutamine inhibits signaling proteins that activate protein degradation, but does not affect proteins that activate protein synthesis after an acute resistance exercise. Amino acids47(7), 1389-1398.