What is Methylation and How Can Methylated Folate Help?

///What is Methylation and How Can Methylated Folate Help?

The Role of Vitamins

A vitamin is any group of organic compounds essential for nutrition and normal growth. Vitamins are required in various quantities through diet, and fulfill specific roles within the body related to health, wellness and proper bodily function. Since vitamins are not naturally synthesized by our bodies, it is crucial that they are obtained via food and/or supplements. Additionally, vitamins must be available in their active form to be used efficiently in the body. To decide what is best for your health, it is important to understand the different forms of vitamins available on the market.


What is Methylation?

Methylation is a biochemical process within our bodies that is essential for the proper function of our internal systems. It occurs billions of times each second, and plays a large role in DNA repair and detoxification. It is also vital for converting water-soluble vitamins into their fat soluble, or active, forms. From a chemical standpoint, methylation is the process of adding a methyl group(s) to a molecule. This changes how that molecule responds to other internal substances, and alters the way that molecule is processed by the body.

Methylated Folate and Methylation

Sustaining the methylation process within the body requires optimal levels of B vitamins, particularly folate (B9). Without sufficient vitamin B levels, the methylation process becomes less efficient, which can have a severely negative impact overall health. However, B vitamins alone may not be enough.

Many people are genetically predisposed to having inadequate methylation. As much as 60% of the US population possesses a genetic defect inhibiting the process of turning folate into its active component, methylated folate. Methylated folate, or 5-MTHF, is one of the most important B vitamins required for methylation, and has become more important than ever to obtain since so many have this deficiency.


Vitamin B9: Folate vs. Folic Acid

Many supplements and processed foods on the market today contain a synthetic form of folate known as folic acid. For many years, folic acid was thought to be absorbed more efficiently than naturally-occurring folate. However, research has consistently shown the opposite.

Most folic acid is not converted to its active form B9 (methylated folate) in the digestive system, but rather in the liver or other bodily tissues. This process leaves un-metabolized folic acid in the bloodstream, and is associated with various health concerns. As such, many medical professionals recommend supplementing with methylated folate rather than folic acid.


Vitalah® is proud to use methylated folate (5-MTHF) in all Oxylent® formulas to ensure our customers receive the highest quality folate available in its most active form. Adding Oxylent® such as the 5-in-1 Multivitamin Effervescent Supplement Drink to your daily nutritional regimen may support methylation and overall health.

Oxylent® offers exclusive, award-winning formulas with the latest science in personal nutrition to consumers worldwide. It’s our goal to ensure all products have the highest quality ingredients to deliver the nutritional formulas your body deserves.


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Winkels RM, Brouwer IA, Siebelink E, Katan MB, Verhoef P. Bioavailability of food folates is 80% of that of folic acid. AM J Clin Nutr. 2007 Feb; 85(2):465-73.